Featured Publications
PET Imaging Using 89Zr Labeled StarPEG Nanocarriers Reveals Heterogeneous Enhanced Permeability and Retention (EPR) in Prostate Cancer
The enhanced permeability and retention (EPR) effect controls passive nanodrug uptake in tumors, and may provide a high tumor payload with prolonged retention for cancer treatment. However, EPR-mediated tumor uptake and distribution vary by cancer phenotype. Thus, we hypothesized that a companion PET-imaging surrogate may benefit EPR-mediated therapeutic drug delivery. We developed two 89Zr-radiolabeled nanocarriers based on 4-armed-starPEG40kDa with or without talazoparib (TLZ), a potent PARPi, as surrogates for the PEG-TLZ4 therapeutic scaffold.
2024
June 2024
Protocol for producing hyperpolarized 13C-bicarbonate for clinical MRI of extracellular pH in aggressive tumors
Authors: Changhua Mu, Xiaoxi Liu, Andrew Riselli, James Slater, Evelyn Escobar, Duy Dang, Scott Drapeau, Romelyn Delos Santos, Stacy Andosca, Hao Nguyen, Peder E Z Larson, Robert Bok, Daniel B Vigneron, John Kurhanewicz, David M Wilson, Robert R Flavell
May 2024
Prostate-Specific Membrane Antigen Targeted StarPEG Nanocarrier for Imaging and Therapy of Prostate Cancer
Authors: Niranjan Meher, Gary W. Ashley, Kondapa Naidu Bobba, Anju Wadhwa, Anil P. Bidkar, Chandrashekhar Dasari, Changhua Mu, Ramya Ambur Sankaranarayanan, Juan A. Camara Serrano, Athira Raveendran, David P. Bulkley, Rahul Aggarwal, Nancy Y. Greenland, Adam Oskowitz, David M. Wilson, Youngho Seo, Daniel V. Santi, Henry F. VanBrocklin, Robert R. Flavell
Prostate-Specific Membrane Antigen Targeted StarPEG Nanocarrier for Imaging and Therapy of Prostate Cancer
Authors: Niranjan Meher, Gary W. Ashley, Kondapa Naidu Bobba, Anju Wadhwa, Anil P. Bidkar, Chandrashekhar Dasari, Changhua Mu, Ramya Ambur Sankaranarayanan, Juan A. Camara Serrano, Athira Raveendran, David P. Bulkley, Rahul Aggarwal, Nancy Y. Greenland, Adam Oskowitz, David M. Wilson, Youngho Seo, Daniel V. Santi, Henry F. VanBrocklin, Robert R. Flavell
Actinium-225 targeted alpha particle therapy for prostate cancer
Authors: Anil P Bidkar, Luann Zerefa, Surekha Yadav, Henry F VanBrocklin, Robert R Flavell
March 2024
CD46-Targeted Theranostics for PET and 225Ac-Radiopharmaceutical Therapy of Multiple Myeloma
Authors: Anju Wadhwa, Sinan Wang, Bonell Patiño-Escobar, Anil P Bidkar, Kondapa Naidu Bobba, Emily Chan, Niranjan Meher, Scott Bidlingmaier,
Yang Su, Suchi Dhrona, Huimin Geng, Vishesh Sarin, Henry F VanBrocklin, David M Wilson, Jiang He, Li Zhang, Veronica Steri, Sandy W Wong,
Thomas G Martin, Youngho Seo, Bin Liu, Arun P Wiita, Robert R Flavell
January 2024
Development of CD46 targeted alpha theranostics in prostate cancer using 134Ce/225Ac-Macropa-PEG4-YS5
Authors: Kondapa Naidu Bobba, Anil P Bidkar, Anju Wadhwa, Niranjan Meher, Suchi Drona, Alexandre M Sorlin, Scott Bidlingmaier,
Li Zhang, David M Wilson, Emily Chan, Nancy Y Greenland, Rahul Aggarwal, Henry F VanBrocklin, Jiang He, Jonathan Chou, Youngho Seo,
Bin Liu, Robert R Flavell
2023
November–December 2023
P-171 - StarPEG Nanocarriers for Prostate Cancer Imaging and Drug Delivery
Authors: Niranjan Meher, Gary Ashley, Anil Bidkar, Anju Wadhwa, Kondapa Bobba, Suchi Dhrona, Shaun Fontaine,
Denis Beckford-Vera, Cyril Fong, David Wilson, Youngho Seo, Daniel Santi, Henry VanBrocklin, Robert Flavell
November 2023
Clinically Translatable Hyperpolarized 13C Bicarbonate pH Imaging Method for Use in Prostate Cancer
Authors: Changhua Mu, Xiaoxi Liu, Yaewon Kim, Andrew Riselli, David E Korenchan, Robert A Bok, Romelyn Delos Santos, Renuka Sriram,
Hecong Qin, Hao Nguyen, Jeremy W Gordon, James Slater, Peder E Z Larson, Daniel B Vigneron, John Kurhanewicz, David M Wilson, Robert R Flavell
July 2023
Evaluation of 134Ce/134La as a PET Imaging Theranostic Pair for 225Ac α-Radiotherapeutics
Authors: Kondapa Naidu Bobba, Anil P Bidkar, Niranjan Meher, Cyril Fong, Anju Wadhwa, Suchi Dhrona, Alex Sorlin, Scott Bidlingmaier,
Becka Shuere, Jiang He, David M Wilson, Bin Liu, Seo, Henry F VanBrocklin, Robert R Flavell
May 2023
Treatment of Prostate Cancer with CD46-targeted 225Ac Alpha Particle Radioimmunotherapy
Authors: Anil P Bidkar, Sinan Wang, Kondapa Naidu Bobba, Emily Chan, Scott Bidlingmaier, Emily A Egusa, Robin Peter, Umama Ali, Niranjan Meher,
Anju Wadhwa, Suchi Dhrona, Chandrashekhar Dasari, Denis Beckford-Vera, Yang Su, Ryan Tang, Li Zhang, Jiang He, David M Wilson, Rahul Aggarwal,
Henry F VanBrocklin, Youngho Seo, Jonathan Chou, Bin Liu, Robert R Flavell
February 2023
PSMA-Targeted Nanotheranostics for Imaging and Radiotherapy of Prostate Cancer
Authors: Niranjan Meher, Henry F VanBrocklin, David M Wilson, Robert R Flavell
2022
November 2022
Prostate-Specific Membrane Antigen Targeted Deep Tumor Penetration of Polymer Nanocarriers
Authors: Niranjan Meher, Gary W Ashley, Anil P Bidkar, Suchi Dhrona, Cyril Fong, Shaun D Fontaine, Denis R Beckford Vera, David M Wilson, Youngho Seo,
Daniel V Santi, Henry F VanBrocklin, Robert R Flavell
2021
November 2021
Synthesis and Preliminary Biological Assessment of Carborane-Loaded Theranostic Nanoparticles to Target Prostate-Specific Membrane Antigen
Authors: Niranjan Meher, Kyounghee Seo, Sinan Wang, Anil P Bidkar, Miko Fogarty, Suchi Dhrona, Xiao Huang, Ryan Tang, Charles Blaha, Michael J Evans,
David R Raleigh, Young-Wook Jun, Henry F VanBrocklin, Tejal A Desai, David M Wilson, Tomoko Ozawa, Robert R Flavell
June 2021
Tumor Microenvironment Biosensors for Hyperpolarized Carbon-13 Magnetic Resonance Spectroscopy
Authors: Changhua Mu, David E Korenchan, Sinan Wang, David M Wilson, Robert R Flavell
March 2021
Molecular Imaging of Prostate Cancer Targeting CD46 Using ImmunoPET
Authors: Sinan Wang, Jun Li, Jun Hua, Yang Su, Denis R Beckford-Vera, Walter Zhao, Mayuri Jayaraman, Tony L Huynh, Ning Zhao, Yung-Hua Wang,
Yangjie Huang, Fujun Qin, Sui Shen, Daniel Gioeli, Robert Dreicer, Renuka Sriram, Emily A Egusa, Jonathan Chou, Felix Y Feng, Rahul Aggarwal,
Michael J Evans, Youngho Seo, Bin Liu, Robert R Flavell, Jiang He
Oral Presentations
2023
November–December 2023
Oral Presentation: Molecular imaging and radiopharmaceutical therapy of Multiple Myeloma targeting CD46 using 89Zr and 225Ac-YS5
Authors: Anju Wadhwa, Sinan Wang, Bonell Escobar, Anil Bidkar, Kondapa Bobba, Niranjan Meher, Suchi Dhrona, Sandy Wong, David Wilson,
Henry VanBrocklin, Youngho Seo, Bin Liu, Arun Wiita, Robert Flavell
Oral Presentation: StarPEG Nanocarriers for PSMA Targeted Radioligand Imaging and Therapy
Authors: Anil Bidkar, Niranjan Meher, Gary Ashley, Anju Wadhwa, Kondapa Bobba, Becka Shuere, David Wilson, Youngho Seo, Daniel Santi,
Henry VanBrocklin, Robert Flavell
Oral Presentation: O-14 - Evaluation of 134Ce/La pair as a PET imaging surrogate for 225Ac radiotherapeutics
Authors: Kondapa Bobba, Anil Bidkar, Niranjan Meher, Cyril Fong, Anju Wadhwa, Suchi Dhrona, Alexandre Sorlin, Scott Bidlingmaier, Becka Shuere,
Jiang He, David Wilson, Bin Liu, Youngho Seo, Henry VanBrocklin, Robert Flavell
2022
November–December 2022
Oral Contributions: O-46 - Treatment of prostate cancer xenografts with the targeted alpha-particle nanogenerator [225Ac]Ac-DOTA-YS
Authors: Anil Bidkar, Sinan Wang, Kondapa Bobba, Scott Bidlingmaier, Yang Su, Emily Egusa, Ryan Tang, Jonathan Chou, Rahul Aggarwal, Jiang He, Youngho Seo, Bin Liu, Robert Flavell
May–June 2022
Oral Presentation: O-08 - Efficient chelation of 134Ce/La using the macrocyclic chelators DOTA and Macropa as potential PET imaging agents
Authors: Kondapa Bobba, Cyril Fong, Anil Bidkar, Ryan Tang, Scott Bidlingmaier, Bin Liu, Youngho Seo, Henry VanBrocklin, Robert Flavell
Oral Presentation: O-46 - CD46 targeted, Actinium-225 labeled antibody for the treatment of prostate cancer xenografts
Authors: Anil Bidkar, Sinan Wang, Kondapa Bobba, Scott Bidlingmaier, Yang Su, Emily Egusa, Ryan Tang, Jonathan Chou, Rahul Aggarwal, Jiang He,
Youngho Seo, Bin Liu, Robert Flavell
Poster Presentations
2023
November–December 2023
Poster Presentation: Alpha particle therapy for the treatment of metastatic tumors of prostate cance
Authors: Anil Bidkar, Anju Wadhwa, Kondapa Bobba, Niranjan Meher, Scott Bidlingmaier, Emily Egusa, Umama Ali, Suchi Dhrona, Yang Su, Jiang He, David Wilson, Rahul Aggarwal, Henry VanBrocklin, Youngho Seo, Jonathan Chou, Robert Flavell
2022
May–June 2022
Poster Presentation: P-003 - Influence of short PEG linkers on biodistribution of 225Ac-Macropa-YS5, an immunoconjugate for treating CD46 expressing cance
Authors: Kondapa Bobba, Anil Bidkar, Sinan Wang, Scott Bidlingmaier, Ryan Tang, Yang Su, Henry VanBrocklin, Bin Liu, Youngho Seo, Robert Flavell
